MEANT 'JOURNAL OF NERUROSCIENCE'

This Week in The Journal*
Next Section Cellular/Molecular

* IT IS INCORRECT THAT THE TITLE HERE DOES NOT CONTAION FUL CITATION
AND CAN BE MISAPPLIED SOMEWHERE ELSE.

mGluRs Induce Anti-Hebbian LTP in Hippocampal Interneurons

Caroline Le Duigou and Dimitri M. Kullmann

(see pages 5777–5781)

The hippocampus has numerous interneuron types that differ in
morphology, molecular profile, electrophysiological properties,
function in feedback versus feedforward inhibition, and synaptic
plasticity. Some interneurons undergo Hebbian long-term potentiation
(LTP) when high-frequency afferent stimulation is paired with
postsynaptic depolarization. This LTP requires metabotropic glutamate
receptors (mGluRs), but not NMDA receptors (NMDARs). In contrast, some
interneurons undergo an anti-Hebbian form of LTP when afferent
stimulation is paired with postsynaptic hyperpolarization. This LTP is
also NMDAR independent, and it requires calcium-permeable AMPA
receptors. In previous studies, activation of mGluRs did not induce
LTP in hyperpolarized interneurons, indicating that Hebbian and anti-
Hebbian LTP use distinct mechanisms. But Le Duigou and Kullmann argue
that previously used recording techniques precluded detection of anti-
Hebbian LTP. They found that mGluR agonists induced LTP in
hyperpolarized interneurons and mGluR antagonists reduced induction of
anti-Hebbian LTP by high-frequency afferent stimulation of
hyperpolarized interneurons. Thus mGluRs appear to contribute to both
anti-Hebbian and Hebbian LTP.

THIS IS ON PUBLICALLY ACCESIBLE PART OF WEB FOR SfN ( IN PUBLIC
DOMAIN).

 IT IS NOT TAHT COMPLICATED FOR THE GRADUATE STIDENTS OF THE RELATED
SCIENCES - NEUROSCIENCES BUT OTHER WISE IS NOT EASY - WILL HAVE TO USE
A LOT OF DICTIONARY AND TRANSLATION FROM THE DICTINARYA ND STILL NOT
SURE THAT THERE IS NOT THE OTEHER GUY CALLED 'HEBB':))

SENATOR kERRY HAS MY LEGISLATICE PROPOPSAL TO SEPARATE THE
PROFESSIOANL DATA BASES FROM THE PUBLIC EDUCATION; I AM NOT THE
DECIDENT HERE BUT THIS PARTICULAR SCIENCE ASSOCIATION MIGHT HAVE THE
INTERESTS NOT JUST THE PUBLIC NOT TO HAVE THIS MATERIAL PUBLICALLY
ACCESSIBLE FOR MAIN REASON - OUTSIDE READER CAN NOT UNDERSTAND IT
WITHOUT THE DICTIONARY -  AND EVEN TRANSLATIONAL SERVICE ON THE TOP
( WHEN APPLICABLE). INTEREST OF THE PUBLIC AND SCIENEC HAVE TO BE
TESTED DURING SUCH DECISION. I AM SURE SENATOR CAN EVEN DO IT WITHOUT
ADDITIONAL EXPERTS. WHY WAIT?

 SENATOR KERRY NEEDS TO HURRY UP BEFORE THE COMAPANY THAT WILL BE
BLAMED FOR THE PROBLEM TOOK IT FROM THE PUBLIC WEB BUT MARKED AS
PROFESSIOANL AND BASED IN BASIC RESEACH; THAT IS  ONE SCENARIO ONLY.

The wrong generalization eb to have a test for it and interpreting
that peopel who do not have it can not learn. nOW MANY MANY nato
SCIETISTS TAHT i ENCOUTERED ARE DAMN FIOUNDED; SO ARE ELITES AROUND
GATES; SO IS PART OF SENATE. ISSUE IS - THSI BELONGS TO TEH EXOERT
WITH CREDENTIALS AND NOT TO ARMY OR SENATOR TO APLY THE BASIC RESEACH.

THERE IS NOW STRANGE RESISTENCE FROM MORONS  ( SORRY) THAT THEY WILL
NOT BE ABLE TO FASHION THE FASCIST ( HITLER ) CRITERION ON REGULARY
PEOPLE. SUCH CONCLUDING  FOR APPLICATION OF THSI BASIC RESEARCH
WILL NOT BE ONLY WRONG POLITICALLY - IT IS WRONG MERITORICALLY - THE
RESEACH THAT FOUND THE RELATIONSHIP DID NOT TEST THIS HYPOTHESES
AND THERE ARE NUMBER OF OTHER EXPLANATIONS; AND NOWHERE THAT
 BASIC RESEACH FOUND  THAT THE PROTEIN IS ESSENSTIAL FOR LEARNING
( MORONS ARE MOUNING AS TEHYB THINKN THAT TEHY CAN CONCLUDE THAT)


 ( SCIENCE CONTROLS FOR SUCH SLIPS IN REASONING THAT ALL
MORONS HERE ARE READY FOR)

MORONS, SCIETISTS IS A PROFESSIOPN AND THE NOBLE ONE; YOU ARE
NOT THE ONE.